Analysis of neonatal diseases constitution and incidence situation / 重庆医学

Objective To analyze the multiple indicators of neonates morbidity to provide reference for treatment and preven‐tion of newborns and improve the neonatal birth and survival quality .Methods Totally 3 542 neonates delivered in the obstetric de‐partment of our hospital from January 1 ,2013 to December 31 ,2014 were investigated .The multiple item data included the birth in‐formation ,clinical manifestations ,treatment and prognosis ,and so on .The data were analyzed by the SPSS17 .0 software ,the χ2 test was adopted to conduct the comparison ,P<0 .05 was considered as statistically significant difference .Results The top three neo‐natal diseases with highest incidence were neonatal pathologic jaundice (11 .06% ) ,neonatal pneumonia (10 .43% ) ,and premature (8 .13% ) .Conclusion It should be to strengthen the health care during pregnancy and neonatal monitoring ,reduce the infection in‐cidence ,find out the causes leading bilirubin increase ,actively conduct the symptomatic treatment ,prevent and treat premature de‐livery and improve the survival rate and survival quality of premature infants .

Treatment of Ph-adult acute lymphoblastic leukemia patients with Tongji-96 regimen / 中华血液学杂志

<p><b>OBJECTIVE</b>To investigate the efficacy and side effects of the consecutive chemotherapeutic protocol, Tongji-96, for adult patients with Philadelphia chromosome negative acute lymphoblastic leukemia (Ph-aALL).</p><p><b>METHODS</b>A retrospective analysis was conducted on 95 cases of Ph-aALL patients treated between January 2004 and December 2012 with Tongji-96 regimen in Tongji hospital, Shanghai.</p><p><b>RESULTS</b>Among these 95 patients, the overall complete remission (CR) rate was 92.6%, 7-year overall survival (OS) and event-free survival (EFS) rates were (39.3±5.9)% and (31.5±5.3)%, respectively, with the median survival of 28 months. Based on multivariable COX proportional hazards regression model analysis, patients with the poor karyotype and failed to achieve CR after first course induction therapy had a higher risk of mortality compared to those who had good or normal cytogenetics and achieved CR after 1 course of induction treatment [the risk ratios (RR) were 3.380 (95% CI 1.530-7.463, P=0.003) and 3.005 (95% CI 1.522-5.933, P=0.002)，respectively]. By means of Kaplan-Meier analysis and Log-rank test，patients aged less than 60 years and successively achieved CR after first induction therapy had more favorable 7-year OS and EFS rates. Patients with normal karyotype and hyperdiploidy had significantly higher 2-year OS and EFS rates compared with those with complex karyotype, t(4;11) translocation and other karyotypes.</p><p><b>CONCLUSION</b>Age (60 years as the cut-off)，treatment courses for achieving CR and cytogenetics were predictive factors for the prognosis of Ph-aALL from this retrospective study. As a comprehensive and sequential therapy protocol, Tongji-96 regimen was proved to obtain long-term survival, reduce risks for relapse and improve outcomes for part Ph-aALL patients.</p>

Prevention and quarantine status of MDRO infection in hospital and quality improvement / 重庆医学

Objective To understand the related knowledge awareness rate of multi-drug resistant organisms (MDRO) infection and the implementation situation of prevention and isolation system in the medical staffs of our hospital .Methods The self -made questionnaire and on-the-spot investigation were adopted to understand the relevant knowledge and awareness of prevention and segregation of MDRO infection among medical staffs and patients in our hospital .Results The related knowledge awareness rate of MDRO in the doctor group was significantly higher than that in the nursing group ,the awareness rate in the patients and family members was very low .There was great difference in compliance to prevent isolation measures between doctors and nurses .Conclu-sion Strengthening the training of nurses ,strengthening the health education to patients and their families ,reinforcing the respon-sibility of hospital infection control group and implementing the detail management are the effective pathway for increasing the pre-vention and segregation of MDRO .